List: Halogen-containing natural products

by likeorhate

•  Chloramphenicol

  Chloramphenicol is a bacteriostatic antimicrobial. It is considered a prototypical broad-spectrum antibiotic, alongside the tetracyclines. Chloramphenicol is effective against a wide variety of Gram-positive and Gram-negative bacteria, including most anaerobic organisms.

  

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•  Thyroxine

  Thyroxine, or 3,5,3',5'-tetraiodothyronine (often abbreviated as T4), a form of thyroid hormones is the major hormone secreted by the follicular cells of the thyroid gland. Thyroxine is synthesized via the iodination and covalent bonding of the phenyl portions of tyrosine residues found in an initial peptide, thyroglobulin, which is secreted into thyroid granules. These iodinated diphenyl compounds are cleaved from their peptide backbone upon being stimulated by thyroid stimulating hormone.

  

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•  Tyrian purple

  Tyrian purple, also known as royal purple, imperial purple or imperial dye, is a purple-red dye first produced by the ancient Phoenicians. Tyrian purple was expensive: the 4th-century-BC historian Theopompus reported, "Purple for dyes fetched its weight in silver at Colophon" in Asia Minor. The expense rendered purple-dyed textiles status symbols, and early sumptuary laws dictated and forbade their use.

  

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•  Trifluoroacetic acid

  Trifluoroacetic acid (TFA) is the simplest stable perfluorinated carboxylic acid chemical compound with the formula CF3CO2H. It is a strong carboxylic acid due to the influence of the electronegative trifluoromethyl group. TFA is almost 100,000-fold more acidic than acetic acid. TFA is widely used in organic chemistry.

  

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•  Halomon

  Halomon is a polyhalogenated monoterpene first isolated from the marine red algae Portieria hornemannii. Halomon has attracted research interest because of its promising profile of selective cytotoxicity that suggests its potential use as an antitumor agent. Halomon is in a class of chemical compounds known as halocarbons, which are often potent alkylating agents which may be toxic to individual cells or to living organisms.

  

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•  Radicicol

  Radicicol, also known as monorden, is a natural product that binds to Hsp90 (Heat Shock Protein 90) and alters its function. HSP90 client proteins play important roles in the regulation of the cell cycle, cell growth, cell survival, apoptosis, angiogenesis and oncogenesis.

  

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•  4-Chloroindole-3-acetic acid

  4-Chloroindole-3-acetic acid (4-Cl-IAA) is a natural plant hormone. It is a member of the class of compounds known as auxins and a chlorinated derivative of the more common auxin indole-3-acetic acid (IAA). 4-Cl-IAA is found in the seeds of a variety of plants, particularly legumes such as peas and broad beans. It is hypothosized that 4-Cl-IAA may be a "death hormone" that maturing seeds use to trigger death of the parent plant by mobilizing nutrients to be stored in the seed.

  

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